Agreement of Central Corneal Thickness and Anterior Chamber Depth between Oculus Pentacam and Advanced Anterior Segment Optical Coherence Tomograph (CSO MS-39)

Doi: 10.36351/pjo.v42i4.2351

Abstract

Purpose:  To access the agreement between central corneal thickness and anterior chamber depth using two anterior segment imaging devices, Oculus Pentacam and CSO MS-39.

Study Design:  Cross-sectional study.

Place and Duration of Study:  Amanat Eye Hospital from July 2025 to October 2025.

Methods:  A total of 263 patients were included through consecutive sampling. Patients aged 18 years or above having clear corneas, no active ocular surface disease and no history of ocular surgery or corneal refractive procedures were included in this study. Central corneal thickness (CCT) and anterior chamber depth (ACD) were determined for each eye using the Oculus Pentacam and Advanced Anterior Segment Optical Coherence Tomograph (CSO MS-39). Paired t-test, Correlation analysis, and Bland-Altman plots were used to estimate mean differences and limits of agreement between the two devices.

Results:  The paired t-test showed no statistically significant changes between Pentacam and MS-39 for CCT and ACD measurements. The CCT mean difference was -0.51µm (p=0.4189), while for ACD the mean difference was -0.0154mm(p=0.2115). Interclass correlation analysis demonstrated excellent reliability for both CCT (ICC = 0.956, 95% CI: 0.945–0.966) and ACD (ICC = 0.813, 95% CI: 0.768–0.851) values. Bland-Altman analysis showed relatively low mean bias with 95% limits of agreement.

Conclusion:  The Pentacam and MS-39 showed good agreement in measuring CCT and ACD, with no systematic bias and no statistically significant differences. These findings support the use of either instrument for routine clinical evaluation andclinical decision making.