Comparison of Intraocular Pressure Lowering Effect of Travoprost and Timolol / Dorzolamide Combination in Primary Open Angle Glaucoma

Abstract

Purpose: To compare the efficacy of once daily travoprost 0.004% and twice
daily Timolol 0.5% plus dorzolamide 2% combination in primary open angle
glaucoma.
Material and Methods: This study was conducted at outpatient department,
Ophthalmology unit, Khyber Teaching Hospital, Peshawar. Study design was
randomized controlled trial and (group B receiving Timolol 0.5% and
Dorzolamide 2% was considered as control group) the duration of the study was
6 months in which a total of 136 patients were included. All cases included in the
study were diagnosed as cases of primary open angle glaucoma. Patients were
divided into two groups i.e. A and B with each group having 68 patients. Patients
in group A were given Travoprost 0.004% eye drops daily and patients in group
B were given eye drops having combination of Timolol 0.5% and Dorzolomide
2% twice daily. Patients were advised to come at 6 weeks interval for follow up.
At each follow up visit, IOP was recorded.
Results: Mean age in Group A was 53 ± 13.26 years while in Group B was 55 ±
14.31 years. In Group A 56% patients were male and 44% patients were female
where as in Group B 59% patients were male and 41% patients were female.
Our results show that Timolol + Dorzolamide was more effective than Travoprost
as Timolol + Dorzolamide cause reduction in IOP of at least 20% in 84% patients
while Travoprost cause reduction in IOP of at least 20% in 80% patients. Also pvalue
calculated at six week is statistically significant).
Conclusion: Our study concludes that dorzolamide with timolol is more
efficacious than Travoprost in open angle glaucoma.
Key Words: Primary open angle glaucoma, travoprost, Timolol plus
dorzolamide.