Intravitreal Injection of Lucentis and the Vitreomacular Relationship in Patients with Exudative AMD: A Prospective Study

Authors

  • Tahir Islam, Salina Siddiqui, Murtaza Mookhtiar, Louise M. Downey, Mark T. Costen

DOI:

https://doi.org/10.36351/pjo.v31i1.143

Abstract

Purpose: This study aimed to investigate the relationship between intravitreal injections of Lucentis and the vitreomacular surface.

Material and Methods: Central macular thickness (CMT), LogMAR visual acuity and the presence or absence of posterior vitreous detachment (PVD) were noted in Lucentis eligible patients before commencing treatment, and 6 months after initial treatment prospectively. The paired sample t-test repeated measures ANOVA were used.

Results: Of 52 eyes analyzed, 70% were noted to have no PVD prior to injection. Of these, 55% of eyes developed PVD. Comparison of the change in CMT between PVD-induced eyes and pre-existing PVD eyes was statistically significant. PVD induction during treatment was associated with a greater reduction in CMT than in eyes with pre-existing PVD. Conclusions: The induction of PVD may have an effect on CMT in eyes injected with Lucentis, implying a potential therapeutic effect of PVD in exudative AMD.

Key words: Macular, Neovascularization, Age related macular degeneration, Lucentis

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Published

31-03-2015

How to Cite

1.
Mark T. Costen TISSMMLMD. Intravitreal Injection of Lucentis and the Vitreomacular Relationship in Patients with Exudative AMD: A Prospective Study. pak J Ophthalmol [Internet]. 2015 Mar. 31 [cited 2024 May 22];31(1). Available from: https://www.pjo.org.pk/index.php/pjo/article/view/143

Issue

Section

Review Articles