Immediate Effect of Intravitreal Bevacizumab Injection on Intraocular Pressure

Doi:10.36351/pjo.v36i4.1109

  • Rabeeah Zafar Al-Shifa Trust Eye Hospital, Rawalpindi
  • Amna Rizwan Al-Shifa Trust Eye Hospital, Rawalpindi
  • Badar-ud-din Ather Naeem Fauji Foundation Hospital, Rawalpindi
  • Asfandyar Asghar Fauji Foundation Hospital, Rawalpindi 
  • Naila Obaid Fauji Foundation Hospital, Rawalpindi 
Keywords: Bevacizumab, Vascular endothelial growth factor, Intraocular pressure, Goldmann applanation tonometer.

Abstract

Purpose:  To determine the immediate effect of intravitreal Bevacizumab on intraocular pressure (IOP) in eyes with retinal vascular disorders.

Study Design:  Interventional case series.

Place and Duration of Study:  Ophthalmology Department, Fauji Foundation Hospital, Rawalpindi, from January 2019to July 2019.

Methods:  One hundred and thirty one patients were included in this study using non probability consecutive sampling. IOP was measured before intravitreal injection (baseline) and at 5 and 30 minutes post-injection. Descriptive statistics were obtained using SPSS version 21.0.

Results:  One hundred and thirty one eyes of 131 patients were observed for IOP change after intra vitreal injection of Bevacizumab. Among them 23 (18%) were males and 108 (82.4%) were females. Mean age was 57.57 ± 13.09 years. Mean IOP at baseline was 16.16 ± 2.52 mmHg. At 5 minutes after injection, 108 eyes (82.4%) had raised IOP, maximum IOP recorded was 44 mmHg. There was a statistically significant correlation between IOP at baseline and 5 minutes with p = 0.005 (≤0.05). At 30 minutes, 94 eyes (71.7%) had IOP fallen back to normal. Statistically, an insignificant correlation was present between IOP at baseline and 30 minutes (p = 0.081) post-injection. IOP rise was not significantly correlated to gender, age, hypertension and asthma at any interval (p value > 0.05). However, IOP rise was significantly correlated in diabetic patients at 30 minutes.

Conclusion:  IOP elevation has been observed after intravitreal bevacizumab in immediate post-injection period which warrants the monitoring of IOP in this critical period to avoid serious blinding complications.

Key Words:  Bevacizumab, Vascular endothelial growth factor, Intraocular pressure, Goldmann applanation tonometer.

Author Biographies

Rabeeah Zafar, Al-Shifa Trust Eye Hospital, Rawalpindi

Registrar, Department of Pediatric Ophthalmology,

Al-Shifa Trust Eye Hospital, Rawalpindi

Amna Rizwan, Al-Shifa Trust Eye Hospital, Rawalpindi

Registrar, Glaucoma Department,

Al-Shifa Trust Eye Hospital, Rawalpindi

Badar-ud-din Ather Naeem, Fauji Foundation Hospital, Rawalpindi

Professor of Ophthalmology,

Eye Department, Fauji Foundation Hospital, Rawalpindi

Asfandyar Asghar, Fauji Foundation Hospital, Rawalpindi 

 

Professor of Ophthalmology,

Eye Department, Fauji Foundation Hospital, Rawalpindi 

Naila Obaid, Fauji Foundation Hospital, Rawalpindi 

Assistant Professor,

Eye Department, Fauji Foundation Hospital, Rawalpindi 

Published
2020-09-06
How to Cite
1.
Zafar R, Rizwan A, Naeem B- ud- din, Asghar A, Obaid N. Immediate Effect of Intravitreal Bevacizumab Injection on Intraocular Pressure. pjo [Internet]. 6Sep.2020 [cited 29Oct.2020];36(4). Available from: https://www.pjo.org.pk/index.php/pjo/article/view/1109
Section
Original Articles