@article{Mark T. Costen_2015, title={Intravitreal Injection of Lucentis and the Vitreomacular Relationship in Patients with Exudative AMD: A Prospective Study}, volume={31}, url={https://www.pjo.org.pk/index.php/pjo/article/view/143}, DOI={10.36351/pjo.v31i1.143}, abstractNote={<p>Purpose: This study aimed to investigate the relationship between intravitreal injections of Lucentis and the vitreomacular surface.</p> <p>Material and Methods: Central macular thickness (CMT), LogMAR visual acuity and the presence or absence of posterior vitreous detachment (PVD) were noted in Lucentis eligible patients before commencing treatment, and 6 months after initial treatment prospectively. The paired sample t-test repeated measures ANOVA were used.</p> <p>Results: Of 52 eyes analyzed, 70% were noted to have no PVD prior to injection. Of these, 55% of eyes developed PVD. Comparison of the change in CMT between PVD-induced eyes and pre-existing PVD eyes was statistically significant. PVD induction during treatment was associated with a greater reduction in CMT than in eyes with pre-existing PVD. Conclusions: The induction of PVD may have an effect on CMT in eyes injected with Lucentis, implying a potential therapeutic effect of PVD in exudative AMD.</p> <p>Key words: Macular, Neovascularization, Age related macular degeneration, Lucentis</p>}, number={1}, journal={Pakistan Journal of Ophthalmology}, author={Mark T. Costen, Tahir Islam, Salina Siddiqui, Murtaza Mookhtiar, Louise M. Downey,}, year={2015}, month={Mar.} }